2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-128720
    Diethyl oxalpropionate 759-65-9
    Diethyl oxalpropionate is an intermediate for poly((R,S)-3,3-dimethylmalic acid) (PDMMLA) derivative synthesis. PDMMLA derivative can be used in synthesis of nanoparticles and study of warfarin encapsulation and controlled release.
    Diethyl oxalpropionate
  • HY-128734
    Dihydroxyfumaric acid hydrate 199926-38-0 98.75%
    Dihydroxyfumaric acid hydrate is an endogenous metabolite.
    Dihydroxyfumaric acid hydrate
  • HY-128737
    Methyl β-D-Galactopyranoside 1824-94-8 99.93%
    Methyl β-D-Galactopyranoside is an endogenous metabolite.
    Methyl β-D-Galactopyranoside
  • HY-128854
    Dimethyl biphenyl-4,4'-dicarboxylate 792-74-5 99.85%
    Dimethyl biphenyl-4,4'-dicarboxylate (Biphenyl dimethyl dicarboxylate) is a hepatoprotective agent. Dimethyl biphenyl-4,4'-dicarboxylate stimulates the Jak/Stat signaling pathway and induces the expression of IFN-α-stimulated genes, particularly 6-16 and ISG12. Dimethyl biphenyl-4,4'-dicarboxylate inhibits the replication of pregenomic RNA and HBeAg. Polymer micelles loaded with Dimethyl biphenyl-4,4'-dicarboxylate can serve as carriers for the compound. Dimethyl biphenyl-4,4'-dicarboxylate can be used as an auxiliary improving agent for chronic hepatitis. Dimethyl biphenyl-4,4'-dicarboxylate is applicable to research related to chronic hepatitis B.\n
    Dimethyl biphenyl-4,4'-dicarboxylate
  • HY-129357
    CCK-B Receptor Antagonist 2 155412-88-7 98.84%
    CCK-B Receptor Antagonist 2, compound 15b, is a potent and orally active Gastrin/CCK-B antagonist with an IC50 value of 0.43 nM. CCK-B Receptor Antagonist 2 also inhibits gastrin/CCK-A activity with an IC50 of 1.82 μM.
    CCK-B Receptor Antagonist 2
  • HY-129623
    Ethyl nonanoate 123-29-5 98.0%
    Ethyl nonanoate is a rich ester in spirits and its presence is commonly related to the pleasant fruity bouquet of alcoholic beverages. Ethyl nonanoate is an endogenous metabolite.
    Ethyl nonanoate
  • HY-129770
    D-Methionine sulfoxide 21056-56-4 98.74%
    D-methionine sulfoxide is the D-isomer of Methionine sulfoxide. Methionine sulfoxide is an oxidation product of methionine. Methionine is the limiting amino acid in milk or leguminous proteins , which is easily oxidized during the course of storage or processing.
    D-Methionine sulfoxide
  • HY-130465
    7α-Thiospironolactone 38753-76-3 99.85%
    7α-Thiospironolactone is the transformation product of spironolactone (HY-B0561), which can be obtained by the metabolism of Thermomyces lanuginosus.
    7α-Thiospironolactone
  • HY-130587
    Sultosilic acid piperazine salt 57775-27-6 98%
    Sultosilic acid piperazine salt (Piperazine sultosylate; A-585) is a lipid-lowering agent. Sultosilic acid piperazine salt modifies the blood lipids levels, reduces platelet adhesiveness without promoting peroxisomal activity of hepatocytes or producing other adverse side-effects.
    Sultosilic acid piperazine salt
  • HY-130705
    Previtamin D3 1173-13-3 98.68%
    Previtamin D3 is an orally active, thermolabile steroidal compound that generates vitamin D3, as well as biologically inactive lumisterol and tachysterol. Previtamin D3 is synthesized in the skin of humans and rats via the UV-B-mediated photoconversion of 7-dehydrocholesterol. Previtamin D3 lacks direct anti-rachitic activity, and its in vivo activity relies on the vitamin D3 it produces. Previtamin D3 can be used in studies related to rickets and vitamin D metabolism.
    Previtamin D3
  • HY-131105
    Cimbuterol 54239-39-3 99.85%
    Cimbuterol is a β-adrenergic agonist. β-adrenergic agonists act as bronchodilators and tocolytics. β-adrenergic agonists promote growth.
    Cimbuterol
  • HY-131172
    Prucalopride N-oxide 1900715-98-1 98%
    Prucalopride N-oxide is a metabolite of Prucalopride (HY-14151) with motility-enhancing effects.
    Prucalopride N-oxide
  • HY-131268
    O-Desisobutyl-O-n-propyl Febuxostat 1530308-87-2
    O-Desisobutyl-O-n-propyl Febuxostat, extracted from the patent CN 103467412, is an xanthine oxidase inhibitor.
    O-Desisobutyl-O-n-propyl Febuxostat
  • HY-131424
    Glycidyl linoleate 24305-63-3 98%
    Glycidyl linoleate (Linoleic acid glycidyl ester) is an ester product.
    Glycidyl linoleate
  • HY-131448
    A3334 854171-31-6 99.64%
    A3051 is a potent and orally active inhibtor of CXXC5-DVL extracted from patent WO2020079569, has an IC50 of 63.06 nM. A3334 can be used for the research of high fat diet (HFD)-induced and methionine-choline deficient diet (MCD)-induced phenotypes such as obesity, diabetes, and NASH.
    A3334
  • HY-131515
    Tri-Salicylic acid 85531-17-5 98.04%
    Tri-Salicylic acid (Compound III) is a compound with similar properties to salicylic acid. Tri-Salicylic acid can be used in the research of inflammation, obesity, diabetes, and cardiovascular disease.
    Tri-Salicylic acid
  • HY-131576
    Thymidine 5′-diphosphate 491-97-4 98%
    Thymidine 5′-diphosphate (dTDP) is a key product for pyrimidine synthesis in organisms. Thymidine 5′-diphosphate is generated via the phosphorylation of thymidine 5'-monophosphate (dTMP) catalyzed by thymidylate kinase (TMPK), a process requiring ATP and Mg2+. Thymidine 5′-diphosphate is further catalyzed by TMPK into thymidine 5'-triphosphate (dTTP). Detection of Thymidine 5′-diphosphate levels enables the assessment of TMPK activity.
    Thymidine 5′-diphosphate
  • HY-131800
    3'-NH2-ATP 4209-30-7 98%
    3'-NH2-ATP, an ATP analogue, is a potent and competitive inhibitor of ATP, with a Ki of 2.3 μM. 3'-NH2-ATP can be used to synthesis of 3′-Amino-3′-deoxy transfer RNA by incorporation into the 3' terminus of tRNA-C-C.
    3'-NH2-ATP
  • HY-132604
    Fazirsiran 2175009-08-0
    Fazirsiran (ARO-AAT) is a second-generation RNAi agent. Fazirsiran consistes of a cholesterol-conjugated RNAi trigger (chol-RNAi) to selectively reduce Alpha1-antitrypsin (AAT) synthesis and a melittin-derived peptide conjugated to N-acetylgalactosamine (NAG) formulated as the excipient EX1 to promote endosomal escape of the chol-RNAi in hepatocytes. Fazirsiran can be used in the study of Alpha-1 Antitrypsin Deficiency (AATD) liver disease. Alpha-1 antitrypsin deficiency (AATD) is caused by mutations in the alpha-1 antitrypsin (SERPINA1) gene.
    Fazirsiran
  • HY-132888
    NCATS-SM4487 2733617-81-5 98%
    NCATS-SM4487 is a highly selective unique dihydropyrimidine inhibitor against GALK1, with an IC50 value of 0.05 μM.
    NCATS-SM4487
Cat. No. Product Name / Synonyms Application Reactivity